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Follow these steps to add color to your table s border: 1. Select the table by clicking its top-left corner when the cursor becomes an Object Selection icon. 2. Switch to Outline mode by clicking the Outline tab at the top of the page window. Because the table was selected in Step 1, it is delineated by a black rectangle and should be visible without scrolling. 3. Click the small gray triangle to the right of the word table, and then choose borderColor from the pop-up menu that appears, as shown in Figure 13-19.

can regard as transition states. The local energy minima of folding intermediates will be of intermediate G values between the U and N conformations of the protein. The small amount of protein not in the N or U states at any given time during protein folding is present mainly as folding intermediates along the folding pathway. Based on a range of experimental studies, several models have been proposed to explain protein folding. Usually these studies have focused on small proteins such as lysozyme, ribonuclease and bovine pancreatic trypsin inhibitor. Three classical mechanisms for folding have been proposed (Figure 6.5). The framework model postulates that secondary structure forms independently of tertiary structure and that diffusion and coalescence of regions of secondary structure then go on to form tertiary structure (this is also sometimes called the diffusion-collision model). The hydrophobic collapse model suggests rapid collapse of the protein around hydrophobic side-chains and that secondary and tertiary structures form in the consequently restricted conformational space. Both of these models are consistent with the formation of measurable intermediates in the folding pathway. The nucleation model postulates that localized regions of native secondary structure act as nuclei from which correct tertiary structure is propagated. Like the framework model, this proposes formation of tertiary structure as a

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In eucaryotes, most DNA sequences are noncoding, that is they do not code for protein. Examples include satellite DNA, intervening sequences within genes (introns) and regulatory sequences. The latter control gene expression in eucaryotes and, for this reason, is widely studied. Good examples of these are promotor, enhancer and operator sequences which are targets for highly sequence-speci c DNA-binding proteins (frequently called factors). Binding of protein at these sites is responsible for a regulatory effect involving turning expression of a speci c gene on or off.

Figure 27-17: Selecting part of a file to insert into your drawing. 7. Leave your spreadsheet open and click the AutoCAD or AutoCAD LT button on the Windows task bar. Choose Edit Paste Special. Although you could insert this as an Excel Worksheet (or object from your spreadsheet application), to try another method, choose AutoCAD (LT) Entities and click OK. Pick an insertion point near the right of the existing OLE object. 8. The spreadsheet is inserted as a table object, but is very small. Click outside the table to close the MText Editor. Zoom in on the table. Click the lower-right corner of the table and drag its handle down and to the right until the table is the same height as the spreadsheet to its left. 9. Click inside the upper-left cell, press Shift, and click inside the lower-right cell. Choose Properties on the Standard toolbar. In the Properties palette, change the Text Height to .6800. Change the Text Style to WMF-Arial0. (This text style was created when you imported the spreadsheet, to match the original text in the spreadsheet.) Change the Alignment to Middle Center.

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it is expected that the stability of any intermediate level should be higher than the stability of the least stable extreme. Table 4 shows the bracketing design for the full design example presented in Table 2. Note that bracketing was not applied to the batch factor because the FDA regulation requires testing at least three batches to determine a drug product shelf life. Even so, the sampling required for the bracketing design was reduced substantially. The sample size required per time period is 12, a small number when compared to

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