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a This is a very dif cult case The main problem is cerebellar ataxia, with ataxia of gait accompanied by milder limb ataxia and cerebellar dysarthria But the disease process is affecting several other systems: his optic nerves, causing optic atrophy; his spinal cord, giving extensor plantars; and his peripheral nerves, causing are exia and impaired distal vibration sense b This is a condition called Friedreich s ataxia It is a recessively inherited, early-onset form of multisystem degeneration that is classi ed under the term spinocerebellar ataxia It is due to a trinucleotide expansion in the frataxin gene, which is believed to have a role in the function of mitochondria It goes on to affect other systems of the body, causing cardiomyopathy or diabetes mellitus It is very rare, except in clinical exams.

Work went on to cover further railways requirements in the GSM standard. Among the new features were

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You may have considered the possibility of multiple sclerosis, which is a much commoner cause of cerebellar ataxia, optic atrophy and extensor plantars, but rare at this age, not usually gradually progressive and not affecting the peripheral nerves like this If he was much older you would consider alcohol toxicity This is a common cause of ataxia and peripheral neuropathy, but would not readily explain the optic atrophy or extensor plantars c Clearly there are going to be a great many dif cult matters to discuss with the patient and his family as they face the prospect of a progressive, disabling degenerative disease in early adult life But there may be particular issues for the parents in relation to the genetics Firstly, they may feel irrationally guilty that they have unknowingly each carried a genetic mutation that has contributed to their son s illness.

As you move down the marginal costs column of Table 10-1, you can see that marginal costs first fall and then rise: yet another reflection of the fact that LemonAid s production process exhibits increasing returns followed by diminishing returns. Because the second worker produces much more than the first worker but costs the same, the marginal cost falls when the second worker is added. For successive workers, costs keep increasing but marginal output keeps declining, which means marginal costs must rise.

Secondly, they will have worries about his younger siblings, who each have a 25% risk of inheriting the illness too The help of specialists in medical genetics is likely to be invaluable in helping them to approach these issues..

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444 Security, privacy and trust COs are usually placed in locations that are accessible to everyone, including attackers For example, sensor networks are expected to consist of a few hundred nodes that may cover a large area It is impossible to protect each of them from physical or logical attacks Thus, every single node is a possible point of attack In a CO, security is pervasive [87] states that security must be integrated into every component to achieve a secure system Components designed without security can become a point of attack, as [54] shows However, speci c vertical functions to enforce security are available for applications We start by describing how the hardware can be secured Then, several encryption approaches for COs are presented We conclude with a look at routing protocols 4441.

The very last step in my option buying decision-making process is to develop a worst-case scenario for the property under consideration. I do this because I am a pragmatic realist, and I fully understand that there is always a fifty-fifty chance that something could happen during the option period that could prevent me from reselling my option to a third party. And this is why the very first question that I always ask myself when I have a property under serious consideration is this: What is the absolute worst thing that could go wrong after I buy an option on this property, and could I survive it financially In most cases, the worstcase scenario is that the property could be foreclosed on, come under the control of a federal bankruptcy court trustee, or be forfeited to a government agency, or I will not able to sell my option before it expires. In cases like these, the worst that can happen is that I end up losing my option fee. Granted, this is not something that I relish, but I could survive it financially. However, if I came up with a

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