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Some agents damage other cells, such as renal cells, because of the agents biochemical effects Radiation High-energy waves or particles during radiation damage the DNA molecules in cancer cells, resulting in their eventual death Normal cells within the eld of treatment are also killed by radiation therapy which can lead to side effects However, normal cells have the capacity to repair themselves, while the cancer cells do not Side effects of radiation, unlike chemotherapy, are accumulative Acute effects occur within the rst six months of treatment Chronic effects occur after the rst six months Nausea, vomiting, diarrhea, hair loss, and anemia can result from radiation therapy depending on the site of the treatment These side effects generally resolve after the cells have had time to repair and resume normal function The most common side effect of radiation therapy is fatigue.

To follow along with this exercise, copy to your hard drive the slideShow.fla file you find in this chapter s folder on the CD-ROM that accompanies this book. Use your computer operating system utilities to disable the file s read-only attributes.

Long-term effects of radiation therapy are usually the result of permanent cell damage in the area receiving the therapy Examples of chronic side effects are pulmonary pneumonitis, brosis (pulmonary and bladder), and sterility Immunotherapy The use of biological response modi ers (BRMs) to treat cancer is a newer treatment that uses the individual s own.

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Aquifer 1 is in contact with Aquifer 2 in the west of the study area, but does not come into direct contact with the other aquifers in this vicinity. (It is worth noting that we cannot presume that the plane of unconformity is permeable, so that even though these aquifers adjoin each other, they may not be in very good hydraulic connectivity. We could only establish their degree of hydraulic connectivity from additional eld evidence, such as groundwater level data and in situ measurements of aquifer properties.) There is a substantial, synformal segment of Aquifer 2 which is utterly isolated from the

11124 Forward Generation of ITs The forward generation of ITs is reasonably straightforward There are three general techniques for mapping a particular IT (including the Super ET and all the Sub ETs that participate in it) into relations in the RDM Although it is possible to use all three techniques within a single DM, this can be somewhat confusing This should only be done when there are compelling reasons for doing so most of the time, the data modelers should choose one technique and overall strategy to use for most (if not all) of the ITs de ned in the data model In the rst IT transformation technique, each ET involved in the IT is mapped to a separate relation, and each IT connection between the Super ET and Sub ETs is mapped as though it were an Identifying RT.

This means that the SIA attribute types in the Super ET generate new domains in each of the relations corresponding to each of the Sub ETs These domains become the PK of the relation for each Sub ET and also act as an FK connecting back to the relation representing the Super ET In this technique, the SNA attribute types contained in the Super ET can be generated in one of two ways In the rst alternative, we only generate the domains corresponding to these ATs for the relation corresponding to the Super ET In the other alternative, we also generate new domains corresponding to these ATs for each relation corresponding to a Sub ET There is no direct enforcement of Total versus Partial participation in the RDM itself, but some physical modeling languages (PMLs) can enforce the participation via mechanisms such as triggers and cascade constraints.

k = 994, Cluster Count: 10

Similarly, the Disjoint versus Overlapping participation is not directly enforced in the RDM for this rst technique, but some physical modeling languages can enforce these participation avors using similar mechanisms In the second IT transformation technique, there is only a single relation generated for the entire IT con guration In other words, the collection of Super ET, Sub ETs, and the ITs themselves will result in the generation of a single relation containing domains for all the ATs contained in all the ETs participating in the IT Here, the values for the domains are present or empty based on the actual type of ET being stored in the relation; therefore, we also require a special AT to be used to specify which ET the information in a particular instance (row) is intended to represent.